The bio-logical role of invariant chain (Ii) in MHC class II antigen presentation

Foreign antigens are internalized by antigen presenting cells by endocytosis and processed to peptides. To enable presentation of antigenic peptides by MHC class II molecules, these molecules have to be sorted to endosomal compartments where they can meet and bind the peptides. Invariant chain is co...

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Bibliographic Details
Published inImmunology letters Vol. 43; no. 1; pp. 47 - 55
Main Authors Nordeng, Tommy W., Bakke, Oddmund
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.1994
Subjects
Animals
Antigen Presentation - immunology
Antigens, Differentiation, B-Lymphocyte
Biological Transport - immunology
Endosomes
Histocompatibility Antigens Class II - immunology
Histocompatibility Antigens Class II - metabolism
Humans
Intracellular sorting
Invariant chain
MHC class II
Peptide loading
Signal Transduction - immunology
Peptide loading
Invariant chain
MHC class II
Endosomes
Intracellular sorting
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Summary:Foreign antigens are internalized by antigen presenting cells by endocytosis and processed to peptides. To enable presentation of antigenic peptides by MHC class II molecules, these molecules have to be sorted to endosomal compartments where they can meet and bind the peptides. Invariant chain is complexed with MHC class II molecules and contains sorting signals responsible for MHC class II accumulation in endosomes. Invariant chain also has several other features contributing to the immune system's specific combat against invaders.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0165-2478
1879-0542
DOI:10.1016/0165-2478(94)00159-6