The metabolism of cytosine arabinoside as a predictive test for clinical response to the drug in acute myeloid leukaemia

The uptake, deamination (D) and phosphorylation (K) of cytosine arabinoside (AraC) by acute myeloid leukaemic blast cells in short term culture has been studied. There was a wide variation in these parameters but no correlation was found between the values of K, D or K/D with the clinical response o...

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Bibliographic Details
Published inEuropean journal of cancer Vol. 12; no. 7; pp. 567 - 573
Main Authors Smyth, J.F., Robins, A.B., Leese, C.L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.07.1976
Subjects
Adult
Aged
Cells, Cultured
Cytarabine - metabolism
Cytarabine - therapeutic use
Deamination
Female
Freezing
Humans
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - metabolism
Male
Middle Aged
Phosphates - metabolism
Remission, Spontaneous
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Summary:The uptake, deamination (D) and phosphorylation (K) of cytosine arabinoside (AraC) by acute myeloid leukaemic blast cells in short term culture has been studied. There was a wide variation in these parameters but no correlation was found between the values of K, D or K/D with the clinical response of patients to an induction course of chemotherapy utilising a combination of AraC, daunorubicin and adriamycin. Hence measurement of these parameters is of little value in predicting the response of patients to this drug combination.
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ISSN:0014-2964
DOI:10.1016/0014-2964(76)90164-X