Memory and cognitive impairments in a case of long-term trihexyphenidyl abuse

We present a case of long-term trihexyphenidyl (THP) abuse in which memory and cognitive impairments were observed 23 years after the commencement of medication. This case showed a dramatic improvement after withdrawal of THP. Clinical course during admission was followed with psychometric testing a...

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Bibliographic Details
Published inPharmacopsychiatry Vol. 26; no. 2; p. 59
Main Authors Kajimura, N, Mizuki, Y, Kai, S, Suetsugi, M, Yamada, M, Okuma, T
Format Journal Article
LanguageEnglish
Published Germany 01.03.1993
Subjects
Cognition Disorders - chemically induced
Electroencephalography - drug effects
Humans
Male
Memory Disorders - chemically induced
Middle Aged
Psychological Tests
Substance-Related Disorders - complications
Trihexyphenidyl - adverse effects
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Summary:We present a case of long-term trihexyphenidyl (THP) abuse in which memory and cognitive impairments were observed 23 years after the commencement of medication. This case showed a dramatic improvement after withdrawal of THP. Clinical course during admission was followed with psychometric testing and laboratory examinations. The fact that the patient showed no evidence of lowered alertness during the clinical course raises the possibility that THP can primarily induce impairment of memory and cognitive functions. This is supported by the findings on the resting EEG of the patient. This case emphasizes the need to exercise caution in prescribing high doses of anticholinergic agents for long periods, particularly in elderly patients with underlying brain pathology.
ISSN:0176-3679
DOI:10.1055/s-2007-1014343