Plasma arginase as a liver function test

A rapid, sensitive assay for plasma arginase was developed by modifying and combining existing procedures. Normal levels of plasma arginase activity for the rat as well as physiological variations due to starvation or cortisone were determined. Liver damage was produced in rats with carbon tetrachlo...

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Bibliographic Details
Published inJournal of comparative pathology Vol. 81; no. 4; pp. 447 - 454
Main Authors Cargill, C.F., Shields, R.P.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1971
Subjects
Alanine Transaminase - blood
Animals
Arginase - blood
Carbon Tetrachloride Poisoning - complications
Cattle
Centrifugation
Chemical and Drug Induced Liver Injury
Chemistry Techniques, Analytical
Chromatography, Gel
Horses
Liver Diseases - blood
Liver Function Tests
Rats
Urea - blood
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Summary:A rapid, sensitive assay for plasma arginase was developed by modifying and combining existing procedures. Normal levels of plasma arginase activity for the rat as well as physiological variations due to starvation or cortisone were determined. Liver damage was produced in rats with carbon tetrachloride and the extent of damage was evaluated by plasma arginase, plasma glutamic pyruvate transaminase as well as by histopathology. Plasma arginase activity proved to be a sensitive indicator of acute hepatocellular necrosis because the increase in plasma arginase activity was directly proportional to the dose of hepatotoxin and plasma activity was not raised by cirrhosis.
ISSN:0021-9975
1532-3129
DOI:10.1016/0021-9975(71)90071-5