Superoxide dismutase, glutathione peroxidase and thiobarbituric acid-reactive compounds in erythrocytes in Duchenne muscular dystrophy

The activities of erythrocyte Superoxide dismutase and glutathione peroxidase in patients with Duchenne muscular dystrophy were normal compared with healthy male controls, as were the levels of thiobarbituric acid-reactive compounds produced during incubation of erythrocytes in the presence of 10 mm...

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Bibliographic Details
Published inClinica chimica acta Vol. 115; no. 1; pp. 93 - 98
Main Authors Hunter, M.Ian S., Brzeski, Maciej S., de Vane, Philip J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.1981
Subjects
Colorimetry - methods
Erythrocytes - enzymology
Glutathione Peroxidase - blood
Humans
Male
Muscular Dystrophies - enzymology
Peroxidases - blood
Reference Values
Superoxide Dismutase - blood
Thiobarbiturates
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Summary:The activities of erythrocyte Superoxide dismutase and glutathione peroxidase in patients with Duchenne muscular dystrophy were normal compared with healthy male controls, as were the levels of thiobarbituric acid-reactive compounds produced during incubation of erythrocytes in the presence of 10 mmol·l −1 hydrogen peroxide. These results suggest that the chief mechanisms for protecting the erythrocyte membrane from peroxidative damage are unimpaired and do not support the idea that the reported erythrocyte abnormalities in this disease result from increased susceptibility to lipid peroxidation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(81)90110-8