Platelet serotonin uptake in panic disorder patients: A replication study

Platelet serotonin uptake was measured in 29 patients with DSM-III panic disorder or agoraphobia with panic attacks and compared to values obtained in 23 controls. Both the affinity constant ( K m) and the maximal rate of uptake ( V max) were determined in a buffered medium using 14C-serotonin. Pati...

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Published inPsychiatry research Vol. 30; no. 1; pp. 63 - 68
Main Authors Norman, Trevor R., Judd, Fiona K., Burrows, Graham D., McIntyre, Iain M.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.10.1989
Subjects
Adolescent
Adult
Agoraphobia - blood
Anxiety Disorders - blood
Blood Platelets - metabolism
Carbon Radioisotopes
DSM-III
Fear
Female
Humans
Male
Middle Aged
Panic - physiology
Panic attacks
platelets
Serotonin - blood
serotonin uptake
serotonin uptake
Panic attacks
DSM-III
platelets
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Summary:Platelet serotonin uptake was measured in 29 patients with DSM-III panic disorder or agoraphobia with panic attacks and compared to values obtained in 23 controls. Both the affinity constant ( K m) and the maximal rate of uptake ( V max) were determined in a buffered medium using 14C-serotonin. Patients and controls did not differ significantly with respect to age or K m values. A statistically significant difference was observed for V max (mean ± SD = 65 ± 22 pmol/10 8 platelet/min in patients vs. 44 ± 13 pmol/10 8 platelets/min in controls). This finding suggests an overactivity of peripheral serotonergic function in panic disorder, which may also imply a similar dysfunction centrally.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(89)90172-8