Characterization of a promoter region supporting transcription of a novel human β-galactoside α-2,6-sialyltransferase transcript in HepG2 cells

In humans, two transcripts encoding β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1.) have previously been described. One of the transcripts is widely expressed, whereas the other is restricted to mature B-cells. In this study we demonstrate the existence of a third transcript in the hepatoma cel...

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Published inBiochimica et biophysica acta Vol. 1261; no. 1; pp. 166 - 169
Main Authors Aas-Eng, Dordi Anne, Åsheim, Hans Christian, Deggerdal, Arne, Smeland, Erlend, Funderud, Steinar
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 14.03.1995
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Summary:In humans, two transcripts encoding β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1.) have previously been described. One of the transcripts is widely expressed, whereas the other is restricted to mature B-cells. In this study we demonstrate the existence of a third transcript in the hepatoma cell-line HepG2. The expression of this transcript is controlled by a promoter region which efficiently supports transcription in HepG2 cells, and which harbours putative binding sites for liver-enriched and acute phase inducible transcription factors.
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ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/0167-4781(94)00250-7