Characterization of a promoter region supporting transcription of a novel human β-galactoside α-2,6-sialyltransferase transcript in HepG2 cells
In humans, two transcripts encoding β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1.) have previously been described. One of the transcripts is widely expressed, whereas the other is restricted to mature B-cells. In this study we demonstrate the existence of a third transcript in the hepatoma cel...
Saved in:
Published in | Biochimica et biophysica acta Vol. 1261; no. 1; pp. 166 - 169 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
14.03.1995
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In humans, two transcripts encoding β-galactoside α-2,6-sialyltransferase (EC 2.4.99.1.) have previously been described. One of the transcripts is widely expressed, whereas the other is restricted to mature B-cells. In this study we demonstrate the existence of a third transcript in the hepatoma cell-line HepG2. The expression of this transcript is controlled by a promoter region which efficiently supports transcription in HepG2 cells, and which harbours putative binding sites for liver-enriched and acute phase inducible transcription factors. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0167-4781 0006-3002 1879-2634 |
DOI: | 10.1016/0167-4781(94)00250-7 |