Release of progesterone from polyethylene devices in vitro and in experimental animals

Low density polyethylene, homogeneously loaded with 2% progesterone and 12% barium sulfate, was tested as a matrix from which to fabricate biochemically active intrauterine devices. The effect of environment on hormone release from these devices was examined by measuring their progesterone content f...

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Bibliographic Details
Published inContraception (Stoneham) Vol. 6; no. 5; pp. 423 - 431
Main Authors Kalkwarf, D.R., Sikov, M.R., Smith, L., Gordon, R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.1972
Subjects
Animals
Barium Sulfate
Delayed-Action Preparations
Female
Fertility - drug effects
In Vitro Techniques
Intrauterine Devices
Isotonic Solutions
Methods
Peritoneal Cavity
Polyethylenes
Progesterone - analysis
Progesterone - pharmacology
Rats
Reproduction and population
Serum Albumin
Swine
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Summary:Low density polyethylene, homogeneously loaded with 2% progesterone and 12% barium sulfate, was tested as a matrix from which to fabricate biochemically active intrauterine devices. The effect of environment on hormone release from these devices was examined by measuring their progesterone content following various periods of residence in pig and rat uteri, in the peritoneal cavities of rats and in a continuous flow of synthetic tissue fluids. Results of a 4-week study showed that progesterone release rates, while initially high, attained a relatively constant value of 14 μg/day/cm 2 after the sixth day. The release pattern in utero was closely simulated by those in the continuous-flow system and in the rat peritoneal cavity. Both systems are thus inexpensive alternatives to large animals for the testing of progesterone release from future devices.
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ISSN:0010-7824
1879-0518
DOI:10.1016/0010-7824(72)90042-X