Biochemical changes in neurosurgical patients under critical care treated with mannitol

A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and an increase of discriminate osmolality (to 60 mosM/kg H20). A hypothesis about the particular biochemical mechanism, i...

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Bibliographic Details
Published inResuscitation Vol. 8; no. 2; pp. 95 - 100
Main Authors Bracall, A.M., Zanghi, F., Sabato, A.F., De Francisci, G., Bondoli, A.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.06.1980
Subjects
Acid-Base Equilibrium - drug effects
Blood Gas Analysis
Brain Neoplasms - metabolism
Brain Neoplasms - surgery
Humans
Mannitol - therapeutic use
Osmolar Concentration
Potassium - metabolism
Premedication
Sodium - metabolism
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Summary:A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and an increase of discriminate osmolality (to 60 mosM/kg H20). A hypothesis about the particular biochemical mechanism, involving the electrolyte and water distribution, is presented.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0300-9572
1873-1570
DOI:10.1016/0300-9572(80)90015-5