Changes of lung water and cardiovascular parameters during neurosurgical procedures associated with various types of infusion

• Published in: Resuscitation Vol. 10; no. 4; pp. 227 - 233
• Main Authors: Nishimura, Nobuo, Sugi, Takahiro, Hiranuma, Naokazu, Sugawara, Shinya, Saito, Takashi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.1983
• Subjects: Adult; Aged; Blood Pressure; Body Water - analysis; Brain - surgery; Cardiac Output; Female; Fluid Therapy - methods; Hemodilution; Hemodynamics; Humans; Lung - analysis; Male; Middle Aged; Oxygen - blood; left cardiac work index; systolic arterial blood pressure; a-vDO 2; mean pulmonary artery pressure; A-aDO 2; systolic pulmonary artery pressure; SVI; Ap-S; HR; RVSWI; LVSWI; PA-D; stroke volume index; diastolic arterial blood pressure; cardiac output; Vo 2I; PA-S; PA-M; total protein; arterial venous oxygen contents difference; oxygen consumption; right cardiac work index; PVRI; WP; O 2 ext; Alveolar arterial oxygen difference; EVLW; left ventricular stroke work index; pulmonary vascular resistance index; Q s Q t shunt ratio; heart rate; right ventricular stroke work index; RCWI; CI; oxygen extraction ratio; pulmonary capillary wedge pressure; LCWI; central venous pressure; AP-M; systemic vascular resistance index; mean arterial blood pressure; AP-D; CVP; TP; diastolic pulmonary artery pressure; SVRI; extravascular lung water
• ISSN: 0300-9572; 1873-1570
• DOI: 10.1016/0300-9572(83)90025-4

With the Swan-Ganz catheter and double indicator technique cardiovascular parameters and lung water were measured in 16 neurosurgical procedures. Five hundred millilitres of whole blood, Manitol® or Fluosol-DA®, or 1000 ml of lactate-Ringer solution was infused within 30 min, and various parameters were estimated and analysed. Extravascular lung water did not change with either solutions. Fluosol-DA® showed the most powerful pressure effects. With whole blood and Fluosol DA®, cardiac output and oxygen availability increased. Marked hemodilution was observed with the infusion of either Manitol®, Fluosol-DA® or lactate-Ringer solution, but only Fluosol-DA® insured adequate oxygen supply to tissues by increase in oxygen capacity in blood. Fluosol-DA® proved to be one of the suitable colloidal solutions to improve the hemodynamics and hemodilution during operation.