Hepatic clearance of tissue-type plasminogen activator in rats

The clearance of tissue-type plasminogen activator (t-PA) was studied, in rats, by use of a functional assay for t-PA. Half-lives in the circulation were about one minute both for human (melanoma cell-derived) t-PA and for the rat's own t-PA. The clearance of t-PA required an intact liver blood...

Full description

Saved in:
Bibliographic Details
Published inThrombosis and haemostasis Vol. 54; no. 3; p. 661
Main Authors Emeis, J J, van den Hoogen, C M, Jense, D
Format Journal Article
LanguageEnglish
Published Germany 01.01.1985
Subjects
Animals
Liver - metabolism
Male
Metabolic Clearance Rate - drug effects
Monosaccharides - metabolism
Perfusion
Rats
Species Specificity
Tissue Plasminogen Activator - metabolism
Tunicamycin - pharmacology
Online AccessGet more information

Cover

More Information
Summary:The clearance of tissue-type plasminogen activator (t-PA) was studied, in rats, by use of a functional assay for t-PA. Half-lives in the circulation were about one minute both for human (melanoma cell-derived) t-PA and for the rat's own t-PA. The clearance of t-PA required an intact liver blood flow. In isolated liver perfusion experiments the hepatic extraction of t-PA did not require any plasma proteins, including fast-acting t-PA inhibitor. Competition experiments, using monosaccharides, suggested that known hepatic glycoprotein receptors were not involved in hepatic t-PA extraction.
ISSN:0340-6245
DOI:10.1055/s-0038-1660092