Is cutaneous apoprotein B a better discriminator than serum lipoproteins for atherosclerosis?

• Published in: Atherosclerosis Vol. 52; no. 3; pp. 301 - 307
• Main Authors: De Graeve, J., Bouissou, H., Thiers, J.C., Fouet, J., Valdiguié, P.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.1984
• Subjects: Apolipoproteins B - analysis; Apolipoproteins B - blood; Arteriosclerosis - blood; Arteriosclerosis - diagnosis; Arteriosclerosis - metabolism; Atherosclerosis; Cholesterol - analysis; Coronary Angiography; Coronary Disease - blood; Coronary Disease - diagnosis; Coronary Disease - metabolism; Coronary Vessels - pathology; Cutaneous apoprotein B; Humans; Lipids - blood; Male; Middle Aged; Serum apoprotein B; Skin - analysis; Vascular risk; Cutaneous apoprotein B; Serum apoprotein B; Vascular risk; Atherosclerosis
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/0021-9150(84)90060-1

Serum lipids, skin apoprotein B (apo B) and skin cholesterol measurements have been investigated in 2 populations: one with normal coronarography, the other with pathological coronarography. Within these 2 populations there were highly significant differences in serum apo B ( P < 0.001), skin cholesterol ( P < 0.01) and skin apo B ( P < 0.001) levels. Skin apo B is a valuable test because its increase is closely related to the coronary heart disease. From these 2 populations, 2 groups with normal serum apo B (< 1.3 g/1) were selected and compared. No significant differences in the various serum lipids were observed except for triglycerides ( P < 0.05) and serum apo B ( P < 0.05). However, a very significant difference was noticed in the skin apo B ( P < 0.001). With this cutaneous apo B determination it waspossible to foresee coronary heart disease in 75% of patients. This test can be therefore considered useful to predict coronary status.