Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005

Autism spectrum disorders (ASDs) affect 1 in 166 births. Although electroencephalogram (EEG) abnormalities and clinical seizures may play a role in ASDs, the exact frequency of EEG abnormalities in an ASD population that has not had clinical seizures or prior abnormal EEGs is unknown. There is no cu...

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Published inEpilepsy & behavior Vol. 8; no. 1; pp. 267 - 271
Main Authors Chez, Michael G., Chang, Mina, Krasne, Valerie, Coughlan, Carolyn, Kominsky, Matthew, Schwartz, Aaron
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2006
Subjects
Adolescent
Adult
Ambulatory electroencephalogram
Anticonvulsants - therapeutic use
Autism
Autism spectrum disorders
Autistic Disorder - complications
Autistic Disorder - drug therapy
Autistic regression
Child
Child, Preschool
Electroencephalogram abnormalities
Electroencephalography - drug effects
Epilepsy
Epilepsy - complications
Epilepsy - diagnosis
Epilepsy - drug therapy
Female
Humans
Infant
Male
Monitoring, Ambulatory
Polysomnography
Retrospective Studies
Valproic Acid - therapeutic use
Autism spectrum disorders
Ambulatory electroencephalogram
Autism
Electroencephalogram abnormalities
Epilepsy
Autistic regression
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Summary:Autism spectrum disorders (ASDs) affect 1 in 166 births. Although electroencephalogram (EEG) abnormalities and clinical seizures may play a role in ASDs, the exact frequency of EEG abnormalities in an ASD population that has not had clinical seizures or prior abnormal EEGs is unknown. There is no current consensus on whether treatment of EEG abnormalities may influence development. This retrospective review of 24-hour ambulatory digital EEG data collected from 889 ASD patients presenting between 1996 and 2005 (with no known genetic conditions, brain malformations, prior medications, or clinical seizures) shows that 540 of 889 (60.7%) subjects had abnormal EEG epileptiform activity in sleep with no difference based on clinical regression. The most frequent sites of epileptiform abnormalities were localized over the right temporal region. Of 176 patients treated with valproic acid, 80 normalized on EEG and 30 more showed EEG improvement compared with the first EEG (average of 10.1 months to repeat EEG).
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ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2005.11.001