Corticoadrenal and adrenergic overactivity in male patients with chronic myocardial infarction

In a group of 22 patients with chronic myocardial infarction, plasma 11-OH corticoids and urinary free 11-OH corticoids, 17-oxo steroids, dehydroepiandrosterone, epinephrine and norepinephrine were studied in resting conditions. Plasma and urinary 11-OH corticoids as well as catecholamines were sign...

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Bibliographic Details
Published inJournal of steroid biochemistry Vol. 4; no. 4; pp. 427 - 432
Main Authors Argüelles, Amilcar E., Hoffman, Cecilia, Chekherdemian, Mateo, Cervetto, Aureliano
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.07.1973
Subjects
11-Hydroxycorticosteroids - metabolism
17-Hydroxycorticosteroids - metabolism
17-Ketosteroids - urine
Adrenal Glands - physiopathology
Adult
Aged
Carbon Radioisotopes
Cholesterol - blood
Dehydroepiandrosterone - urine
Epinephrine - urine
Humans
Hydrocortisone - metabolism
Lipids - blood
Lipoproteins - blood
Male
Middle Aged
Myocardial Infarction - physiopathology
Norepinephrine - urine
Triglycerides - blood
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Summary:In a group of 22 patients with chronic myocardial infarction, plasma 11-OH corticoids and urinary free 11-OH corticoids, 17-oxo steroids, dehydroepiandrosterone, epinephrine and norepinephrine were studied in resting conditions. Plasma and urinary 11-OH corticoids as well as catecholamines were significantly higher than normal but the opposite was found for dehydroepiandrosterone excretion. Mean cortisol secretion rate was not significantly elevated. The recovered myocardial infarct survivors showed markedly increased epinephrine responses to an audiogenic stress. Many of these patients, although fully recovered after long convalencences, seem to have a glucocorticoid and adrenergic overactivity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-4731
DOI:10.1016/0022-4731(73)90013-7