In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation

We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and...

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Bibliographic Details
Published inOptics letters Vol. 43; no. 11; p. 2450
Main Authors Pagliazzi, M, Sekar, S Konugolu Venkata, Di Sieno, L, Colombo, L, Durduran, T, Contini, D, Torricelli, A, Pifferi, A, Mora, A Dalla
Format Journal Article
LanguageEnglish
Published United States 01.06.2018
Subjects
Adult
Blood Flow Velocity - physiology
Female
Humans
Optical Fibers
Photons
Scattering, Radiation
Spectrum Analysis - methods
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Summary:We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and reduced probe dimensions. Depth discriminating, quasi-null distance measurement of blood flow in a human subject is presented. We envision the miniaturization and integration of matrices of optical sensors of increased spatial resolution and the enhancement of the contrast of local blood flow changes.
ISSN:1539-4794
DOI:10.1364/OL.43.002450