Association between Angiopoietin-2 Gene Polymorphisms and Susceptibility to Coronary Artery Disease

• Published in: Archives of Iranian medicine Vol. 24; no. 8; pp. 622 - 628
• Main Authors: Lan, Luhang, Kang, Le, Lu, Liang, Ge, Xuan, Si, Hongping, Peng, Jiren, Wang, Maofeng, Li, Weimin, Su, Chen-Ming
• Format: Journal Article
• Language: English
• Published: Iran Academy of Medical Sciences of I.R. Iran 01.08.2021
• Subjects: Angiopoietin-2 - genetics; Asians - genetics; Cardiovascular disease; Case-Control Studies; China - epidemiology; Coronary Artery Disease - genetics; Coronary vessels; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; High density lipoprotein; Humans; Polymorphism, Single Nucleotide; Vein & artery diseases; China; Angiopoietin-2; Coronary artery disease; Single nucleotide polymorphism
• ISSN: 1029-2977; 1735-3947
• DOI: 10.34172/aim.2021.88

Angiopoietin-2 (Angpt2) is associated with the progression of coronary artery disease (CAD). This research aimed to investigate the possible association between single nucleotide polymorphisms (SNPs) of and CAD. This research was performed in a hospital from the eastern region of China. From February 2019 to June 2019, 222 patients with CAD were newly diagnosed and 403 healthy controls were confirmed by physical examinations. The distribution frequency of five SNPs of the (rs11137037, rs2442598, rs12674822, rs1823375, and rs734701) in all participants was analyzed by real-time polymerase chain reaction (PCR) with SNP locus-specific probes. Our data showed that the participants with the TT genotype of rs2442598 were at reduced risk of CAD compared with wild-types (adjusted odds ratio [AOR] = 0.511, 95% CI: 0.283-0.923). The participants with the AC and AC+CC genotypes of rs11137037 were at greater risk of CAD compared to wild-types (AOR = 1.754, 95% CI: 1.140-2.699; AOR = 1.731, 95% CI: 1.165-2.573, respectively). In addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype, in addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype ( =0.037). These findings, as well as analysis of the haplotype, clearly indicate that SNPs were highly correlated with susceptibility to CAD among the Han Chinese population.