GM1 ganglioside reduces edema and monoaminergic neuronal changes following experimental focal ischemia in rat brain

Seventy-two hours following a middle cerebral artery occlusion, the associated increase in water content on the ischemic side was significantly reduced by the exogenous administration of monosialoganglioside GM1 (30 mg/kg, i.p.). The levels of dopamine and serotonin on the ischemic side were approxi...

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Published inBrain research Vol. 524; no. 2; p. 313
Main Authors Koga, T, Kojima, H, Yamada, S, Miki, K, Nishi, S, Inanaga, K, Shoji, H, Kaji, M, Jonsson, G, Toffano, G
Format Journal Article
LanguageEnglish
Published Netherlands 06.08.1990
Subjects
Animals
Body Water - physiology
Brain - drug effects
Brain - physiopathology
Brain Edema - drug therapy
Brain Edema - etiology
Brain Edema - physiopathology
Dopamine - metabolism
G(M1) Ganglioside - therapeutic use
Ischemic Attack, Transient - physiopathology
Male
Neurons - drug effects
Neurons - physiology
Rats
Rats, Inbred Strains
Serotonin - metabolism
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Summary:Seventy-two hours following a middle cerebral artery occlusion, the associated increase in water content on the ischemic side was significantly reduced by the exogenous administration of monosialoganglioside GM1 (30 mg/kg, i.p.). The levels of dopamine and serotonin on the ischemic side were approximately 50% and 80% of those on the contralateral non-ischemic side, respectively. Treatment with GM1 (5 times during the first 48 h after occlusion) produced a significant reduction in the levels of dopamine and serotonin loss. The present findings are compatible with the observed protective action of the exogenously administered GM1 following ischemic brain injury.
ISSN:0006-8993
DOI:10.1016/0006-8993(90)90706-H