Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

• Published in: Mutation research Vol. 338; no. 1; pp. 183 - 188
• Main Authors: Ono, T., Miyamura, Y., Ikehata, H., Yamanaka, H., Kurishita, A., Yamamoto, K., Suzuki, T., Nohmi, T., Hayashi, M., Sofuni, T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.1995
• Subjects: Ageing; Aging - genetics; Animals; Female; Hypoxanthine Phosphoribosyltransferase - genetics; Lac Operon; lacZ: Muta ™ mouse; Male; Mice; Mice, Transgenic - genetics; Mutation - genetics; Spleen; Spleen - metabolism; Spontaneous mutation; Transgenes; Spontaneous mutation; Spleen; lacZ: Muta ™ mouse; Ageing
• ISSN: 0921-8734; 0027-5107
• DOI: 10.1016/0921-8734(95)00023-Y

Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta ™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10 −5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10 −5 at one year. Since the mutation of the gene is not likely to be subject to select...