Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta ™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10 −5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10 −5 at one year. Since the mutation of the gene is not likely to be subject to select...

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Bibliographic Details
Published inMutation research Vol. 338; no. 1; pp. 183 - 188
Main Authors Ono, T., Miyamura, Y., Ikehata, H., Yamanaka, H., Kurishita, A., Yamamoto, K., Suzuki, T., Nohmi, T., Hayashi, M., Sofuni, T.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.1995
Subjects
Ageing
Aging - genetics
Animals
Female
Hypoxanthine Phosphoribosyltransferase - genetics
Lac Operon
lacZ: Muta ™ mouse
Male
Mice
Mice, Transgenic - genetics
Mutation - genetics
Spleen
Spleen - metabolism
Spontaneous mutation
Transgenes
Spontaneous mutation
Spleen
lacZ: Muta ™ mouse
Ageing
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Summary:Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta ™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10 −5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10 −5 at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.
ISSN:0921-8734
0027-5107
DOI:10.1016/0921-8734(95)00023-Y