Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age
Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta ™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10 −5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10 −5 at one year. Since the mutation of the gene is not likely to be subject to select...
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| Published in | Mutation research Vol. 338; no. 1; pp. 183 - 188 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.10.1995
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0921-8734 0027-5107 |
| DOI | 10.1016/0921-8734(95)00023-Y |
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| Abstract | Spontaneous mutant frequency of
lacZ gene in spleen of transgenic Muta
™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10
−5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10
−5 at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death. |
|---|---|
| AbstractList | Spontaneous mutant frequency of
lacZ gene in spleen of transgenic Muta
™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10
−5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10
−5 at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death. Spontaneous mutant frequency of lacZ gene in spleen of transgenic MutaTM mouse was examined at different ages. It was (3.2 +/- 1.3 (SD)) x 10(-5) at newborn and increased almost linearly with age up to (8.3 +/- 1.8) x 10(-5) at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death. |
| Author | Nohmi, T. Yamanaka, H. Yamamoto, K. Suzuki, T. Miyamura, Y. Hayashi, M. Sofuni, T. Ono, T. Ikehata, H. Kurishita, A. |
| Author_xml | – sequence: 1 givenname: T. surname: Ono fullname: Ono, T. organization: Department of Radiation Research, Tohoku University School of Medicine, Tohoku University, Aoba-ku, Sendai 980-77, Japan – sequence: 2 givenname: Y. surname: Miyamura fullname: Miyamura, Y. organization: Department of Radiation Research, Tohoku University School of Medicine, Tohoku University, Aoba-ku, Sendai 980-77, Japan – sequence: 3 givenname: H. surname: Ikehata fullname: Ikehata, H. organization: Department of Radiation Research, Tohoku University School of Medicine, Tohoku University, Aoba-ku, Sendai 980-77, Japan – sequence: 4 givenname: H. surname: Yamanaka fullname: Yamanaka, H. organization: Department of Radiation Research, Tohoku University School of Medicine, Tohoku University, Aoba-ku, Sendai 980-77, Japan – sequence: 5 givenname: A. surname: Kurishita fullname: Kurishita, A. organization: Department of Radiation Research, Tohoku University School of Medicine, Tohoku University, Aoba-ku, Sendai 980-77, Japan – sequence: 6 givenname: K. surname: Yamamoto fullname: Yamamoto, K. organization: Department of Biology, Faculty of Science, Tohoku University, Aoba-ku, Sendai 980-77, Japan – sequence: 7 givenname: T. surname: Suzuki fullname: Suzuki, T. organization: Division of Genetics and Mutagenesis, National Institute of Health Science, Tokyo 158, Japan – sequence: 8 givenname: T. surname: Nohmi fullname: Nohmi, T. organization: Division of Genetics and Mutagenesis, National Institute of Health Science, Tokyo 158, Japan – sequence: 9 givenname: M. surname: Hayashi fullname: Hayashi, M. organization: Division of Genetics and Mutagenesis, National Institute of Health Science, Tokyo 158, Japan – sequence: 10 givenname: T. surname: Sofuni fullname: Sofuni, T. organization: Division of Genetics and Mutagenesis, National Institute of Health Science, Tokyo 158, Japan |
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| Cites_doi | 10.1016/0027-5107(93)90109-S 10.1084/jem.171.6.1981 10.1096/fasebj.8.8.8181674 10.1002/jcp.1041210207 10.1016/0047-6374(85)90082-X 10.1016/0027-5107(94)90320-4 10.1093/nar/16.19.9343 10.1093/mutage/8.1.7 10.1093/nar/21.16.3903 10.1016/0168-9525(93)90209-Z 10.1016/0027-5107(92)90186-6 10.1093/mutage/9.3.183 |
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| Keywords | Spontaneous mutation Spleen lacZ: Muta ™ mouse Ageing |
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| Snippet | Spontaneous mutant frequency of
lacZ gene in spleen of transgenic Muta
™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10
−5 at newborn and... Spontaneous mutant frequency of lacZ gene in spleen of transgenic MutaTM mouse was examined at different ages. It was (3.2 +/- 1.3 (SD)) x 10(-5) at newborn... |
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| SubjectTerms | Ageing Aging - genetics Animals Female Hypoxanthine Phosphoribosyltransferase - genetics Lac Operon lacZ: Muta ™ mouse Male Mice Mice, Transgenic - genetics Mutation - genetics Spleen Spleen - metabolism Spontaneous mutation Transgenes |
| Title | Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age |
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