Oxytocin secretion is stimulated by changes in glucose metabolism

Previous studies have shown that infusion of oxytocin into normal dogs increased plasma levels of insulin and glucagon. These responses were accompanied by increased rates of glucose production and overall glucose uptake. The purpose of the present study was to determine whether, conversely, changes...

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Bibliographic Details
Published inProceedings of the Society for Experimental Biology and Medicine Vol. 207; no. 1; p. 38
Main Authors Altszuler, N. (New York University Medical Center, New York, NY.), Fuchs, A.R
Format Journal Article
LanguageEnglish
Published United States 01.10.1994
Subjects
Animals
AZUCAR EN SANGRE
Blood Glucose - metabolism
CHIEN
DIABETE
DIABETES
Dogs
EXPERIMENTACION
EXPERIMENTATION
Female
GLUCOSA
GLUCOSE
HORMONAS
HORMONE
Insulin - pharmacology
INSULINA
INSULINE
Male
Metabolic Clearance Rate
METABOLISME DES GLUCIDES
METABOLISMO DE CARBOHIDRATOS
OCYTOCINE
OXITOCINA
Oxytocin - metabolism
PERRO
SECRECION
SECRETION
SUCRE DU SANG
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Summary:Previous studies have shown that infusion of oxytocin into normal dogs increased plasma levels of insulin and glucagon. These responses were accompanied by increased rates of glucose production and overall glucose uptake. The purpose of the present study was to determine whether, conversely, changes in glucose metabolism would result in changes in oxytocin secretion. In normal dogs, injection of insulin (0.1 U/kg/iv) resulted in increased secretion of oxytocin which coincided with the hypoglycemic nadir, and the oxytocin levels remained elevated for the remaining 60 min, during which time plasma glucose levels were returning to normal. In dogs made diabetic with streptozocin, injection of insulin (1 Ulkgliv) evoked increased oxytocin secretion which began as the plasma glucose levels were falling from the control value of 400 mg/dl to about 170 mg/dl; the oxytocin levels remained above initial values for at least 90 min, during which period plasma glucose returned to normal glycemic values. In normal dogs, infusion of 2-deoxyglucose, which causes intracellular glucopenia, caused a prompt and sustained increase in plasma oxytocin levels. The data suggest that abrupt decreases in avallability of glucose in the central nervous system, as induced experimentally by administration of 2-deoxyglucose or by a rapid fall in peripheral glucose levels, evokes secretion of oxytocin
Bibliography:S20
S30
9531086
ISSN:0037-9727
1525-1373
DOI:10.3181/00379727-207-43788