Comparative study of macrophage response in mice after DNA immunization and infection with herpes simplex virus type 1

• Published in: Bulletin of experimental biology and medicine Vol. 140; no. 6; pp. 716 - 719
• Main Authors: Nagurskaya, E V, Zaitseva, L G, Kobets, N V, Kireeva, I V, Bekhalo, V A, Kozlov, A Yu, Klimova, R R, Gur'yanova, S V, Andronova, T M, Shingarova, L N, Boldyreva, E F, Nekrasova, O V
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.12.2005
• Subjects: Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives; Acetylmuramyl-Alanyl-Isoglutamine - therapeutic use; Animals; Cell Movement; Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use; Herpes Simplex - blood; Herpes simplex virus 1; Herpesvirus 1, Human - metabolism; Macrophages - metabolism; Male; Mice; Mice, Inbred BALB C; Vaccines, DNA - metabolism; Vaccines, DNA - pharmacology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-006-0064-9

Functional activity of macrophages and intensity of T cell immune response in mice were studied after intravaginal and intraperitoneal infection with herpes simplex virus type 1 and DNA vaccination in combination with adjuvant treatment (recombinant granulocyte-macrophage colony-stimulating factor and glucosaminylmuramyl dipeptide). DNA vaccination induced a virus-specific T cell immune response with no macrophagic inflammatory reaction. Infection with herpes simplex virus type 1 was accompanied by sustained inflammation, but not by the T cell immune response.