The effect of midazolam on motility of the sphincter of Oddi in human subjects

Midazolam, a water-soluble benzodiazepine, has recently been introduced and found to be beneficial for sedation in upper GI endoscopy. Whereas it has been proven that diazepam does not have any effect on sphincter of Oddi (SO) motility in humans, no respective data exist on midazolam. On evaluation...

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Bibliographic Details
Published inEndoscopy Vol. 25; no. 6; p. 384
Main Authors Cuer, J C, Dapoigny, M, Bommelaer, G
Format Journal Article
LanguageEnglish
Published Germany 01.08.1993
Subjects
Cholangiopancreatography, Endoscopic Retrograde
Female
Humans
Male
Manometry
Midazolam - pharmacology
Middle Aged
Pressure
Sphincter of Oddi - drug effects
Sphincter of Oddi - physiology
Sphincterotomy, Endoscopic
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Summary:Midazolam, a water-soluble benzodiazepine, has recently been introduced and found to be beneficial for sedation in upper GI endoscopy. Whereas it has been proven that diazepam does not have any effect on sphincter of Oddi (SO) motility in humans, no respective data exist on midazolam. On evaluation of the possible effects of midazolam on SO motility recording by means of endoscopic manometry, we found that midazolam had no effect on basal pressure (24.2 +/- 12.59 mm Hg before and 23.85 +/- 12.63 mm Hg after midazolam, p = 0.55), amplitude (39.75 +/- 22.62 versus 44.55 +/- 27.15, p = 0.097), duration (4.9 +/- 1.8 sec versus 5.05 +/- 1.7 sec, p = 0.614), and frequency of SO contractions (7.75 +/- 1.68 waves/min versus 7.15 +/- 1.92 waves/min, p = 0.083). These results suggest that in patients with normal manometric findings midazolam does not interfere with SO recording.
ISSN:0013-726X
DOI:10.1055/s-2007-1010345