Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade
The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed f...
Saved in:
| Published in | Life sciences (1973) Vol. 35; no. 8; p. 899 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
20.08.1984
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different age groups at various times after EEDQ injection. These results suggest that loss of striatal dopamine receptors during aging may be due to a decreased biosynthetic rate. |
|---|---|
| AbstractList | The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different age groups at various times after EEDQ injection. These results suggest that loss of striatal dopamine receptors during aging may be due to a decreased biosynthetic rate. |
| Author | Roth, G S Henry, J M |
| Author_xml | – sequence: 1 givenname: J M surname: Henry fullname: Henry, J M – sequence: 2 givenname: G S surname: Roth fullname: Roth, G S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6482680$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kEtLw0AcxPdQqW31GyjssQVX__vIJjlKjQ8QRdBz2WcbTbNxk6q5-8E1WDzN8BtmDjNFozrUDqETCucUqLwAYIJwBsk8E4scBJUkG6HJPz5E07Z9BYAkSfkYjaXImMxggr4L753pcPBYrct6jUONozPhw8V-gG0XS9WpCtvQqG1ZuyF1TRdii32oqvA5lB6I6zbhqzcq6lD3FWF7QOgZZsSWm97G8L4r61ANG_OiuHpaYF0F86asO0IHXlWtO97rDL1cF8_LW3L_eHO3vLwnhidpR4QSGQebSJ1byFKX_3qjwFhmlLWUUiV5wlUKxmkhPQjmjc6VToznuU4pm6HTv91mp7fOrppYblXsV_s32A-3qWQT |
| CitedBy_id | crossref_primary_10_1111_j_1749_6632_1988_tb33008_x crossref_primary_10_1016_0024_3205_94_00383_1 crossref_primary_10_1016_S0889_8529_18_30452_3 crossref_primary_10_1016_0006_8993_89_91442_X crossref_primary_10_1016_0169_328X_93_90085_4 crossref_primary_10_1016_0197_4580_87_90039_X crossref_primary_10_1016_0197_4580_86_90023_0 crossref_primary_10_1111_j_1749_6632_1988_tb35269_x crossref_primary_10_1111_j_1748_1716_1988_tb08319_x crossref_primary_10_1007_BF03323891 crossref_primary_10_1016_0006_8993_92_90095_Q crossref_primary_10_1016_0163_7258_89_90046_6 crossref_primary_10_1016_0361_9230_93_90294_L crossref_primary_10_1016_0891_0618_93_90023_W crossref_primary_10_1016_0531_5565_94_00029_3 crossref_primary_10_1016_0091_3057_88_90381_4 crossref_primary_10_1016_0197_4580_94_90148_1 crossref_primary_10_1016_0024_3205_86_90182_7 crossref_primary_10_1016_S0014_2999_00_00032_7 crossref_primary_10_1016_S0169_328X_96_00197_0 crossref_primary_10_1111_j_1749_6632_1994_tb56824_x crossref_primary_10_1016_S1385_299X_97_00012_3 crossref_primary_10_1016_0006_8993_91_91314_Q crossref_primary_10_1016_0006_8993_96_00481_7 crossref_primary_10_1016_S0197_4580_89_80011_9 crossref_primary_10_1016_0014_2999_88_90431_1 crossref_primary_10_1016_0304_3940_87_90362_4 crossref_primary_10_1016_S0197_4580_97_00011_0 crossref_primary_10_1016_0006_8993_87_90100_4 crossref_primary_10_1016_0031_9384_94_90337_9 crossref_primary_10_1016_0165_3806_92_90095_E crossref_primary_10_1016_0014_2999_88_90621_8 crossref_primary_10_1016_0006_8993_87_91595_2 crossref_primary_10_1016_S0028_3908_99_00218_X crossref_primary_10_1111_j_1471_4159_1986_tb13008_x crossref_primary_10_1152_jn_00756_2012 crossref_primary_10_1002_jnr_490310216 crossref_primary_10_1016_0006_8993_96_00683_X crossref_primary_10_1016_0197_4580_87_90056_X crossref_primary_10_1016_S0028_3908_00_00047_2 crossref_primary_10_1111_j_1749_6632_1988_tb32978_x crossref_primary_10_1007_s11357_008_9066_z crossref_primary_10_1016_0197_4580_86_90162_4 crossref_primary_10_1016_0197_4580_87_90002_9 crossref_primary_10_1016_0014_2999_94_90568_1 crossref_primary_10_1016_0197_4580_90_90046_3 crossref_primary_10_1016_0006_8993_89_91108_6 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1016/0024-3205(84)90416-8 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Sciences (General) Biology |
| ExternalDocumentID | 6482680 |
| Genre | Journal Article |
| GroupedDBID | --- -~X .55 .GJ .~1 1RT 3O- 4.4 457 53G 5GY 5RE 5VS 6TJ 7-5 8P~ 9JM AABNK AACTN AAEDW AAHBH AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABFRF ABJNI ABLJU ABMAC ACGFO ACGFS ACIUM ACIWK ACPRK ACRLP ADMUD AEFWE AENEX AFFNX AFRAH AFTJW AGUBO AHHHB AIKHN AITUG ALMA_UNASSIGNED_HOLDINGS ANZVX ASPBG AVWKF AZFZN BLXMC BNPGV CGR CNWQP CS3 CUY CVF DU5 EBS ECM EIF EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID G-2 G-Q HMG HMT HVGLF H~9 IH2 J1W J5H K-O L7B M34 MVM N9A NPM O-L OAUVE P2P Q38 R2- ROL SDF SDG SDP SES SIN SPCBC SPT T5K WUQ X7M Y6R YYP YZZ ZGI ZKB ZXP ~G- |
| ID | FETCH-LOGICAL-c357t-4a4830d56b9d087e90d5ca0cd2cadd111a6353a70ceb46f042fcb9ab5cf39b712 |
| ISSN | 0024-3205 |
| IngestDate | Sat Sep 28 08:35:41 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c357t-4a4830d56b9d087e90d5ca0cd2cadd111a6353a70ceb46f042fcb9ab5cf39b712 |
| PMID | 6482680 |
| ParticipantIDs | pubmed_primary_6482680 |
| PublicationCentury | 1900 |
| PublicationDate | 1984-08-20 |
| PublicationDateYYYYMMDD | 1984-08-20 |
| PublicationDate_xml | – month: 08 year: 1984 text: 1984-08-20 day: 20 |
| PublicationDecade | 1980 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Life sciences (1973) |
| PublicationTitleAlternate | Life Sci |
| PublicationYear | 1984 |
| SSID | ssj0005573 |
| Score | 1.4611268 |
| Snippet | The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 899 |
| SubjectTerms | Aging Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Kinetics Male Quinolines - pharmacology Rats Rats, Inbred Strains Receptors, Dopamine - metabolism Spiperone - metabolism |
| Title | Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/6482680 |
| Volume | 35 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFB62lUJfpK0Wb5V5UNhFR5PJJJk8iq6WogtKC30rc8VFmix2oW6f_eE9JzNJY6tFfQlhZjcM8305t8w5h5BnFtRO4pRgGfcJE6pImS4zy7TgWthUuEyjo_hpVuwfiYPj_Hg0uhhmlyz1K3Px27yS_0EVxgBXzJL9B2T7h8IA3AO-cAWE4fpXGMfSw_gpP_QawtwUg4cy2-_mbUsOTHa04BmfojkJs27R9tfxgH9zjn-aMWwi_WNl1HeNx9QZjwMsxf3nzM6_riwqkHnddEbpdPruMwYUNOjCb8r-cp7o49y7F1GzhkJQVTmM5_Z5EQdXodgvTYjvfIihWBsS86TAwCpPhrKVI-JJPpStoRRJ5JAcCEoZ2iLdEOAhltA_C9YoxXNUmWA4trguB7guTltgCwE-UugHdevktcLacWaNrJUSZeMM4zzd4aA8nk2I6-iSLtPidT82lmIS17VJNuLTrnknrZVyuEXuRveCvglc2SYjV--QjdBwdLVDtqMoP6PjWG98co_8DDSijactjWhT045GONjRiHY0oj2NaE8jeguNXtKbJKJjpNCEdgS6T47eTw_f7rPYnIOZLC-X8FoLmSU2L3RlE1m6Cu6NSozlBlQmaFAFpmymysQ4LQoPusEbXSmdG59Vukz5Llmvm9o9IDQpuUkxVIHVKqXOKw9-bAa_A4WjZKkfkt2wpyeLUIHlJG72oz9NPCabVxR9Qu54eOHdHliPS_20BfoSX0BohA |
| link.rule.ids | 786 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+aging+on+recovery+of+striatal+dopamine+receptors+following+N-ethoxycarbonyl-2-ethoxy-1%2C+2-dihydroquinoline+%28EEDQ%29+blockade&rft.jtitle=Life+sciences+%281973%29&rft.au=Henry%2C+J+M&rft.au=Roth%2C+G+S&rft.date=1984-08-20&rft.issn=0024-3205&rft.volume=35&rft.issue=8&rft.spage=899&rft_id=info:doi/10.1016%2F0024-3205%2884%2990416-8&rft_id=info%3Apmid%2F6482680&rft_id=info%3Apmid%2F6482680&rft.externalDocID=6482680 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0024-3205&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0024-3205&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0024-3205&client=summon |