Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade

The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed f...

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Bibliographic Details
Published inLife sciences (1973) Vol. 35; no. 8; p. 899
Main Authors Henry, J M, Roth, G S
Format Journal Article
LanguageEnglish
Published Netherlands 20.08.1984
Subjects
Aging
Animals
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Kinetics
Male
Quinolines - pharmacology
Rats
Rats, Inbred Strains
Receptors, Dopamine - metabolism
Spiperone - metabolism
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Summary:The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different age groups at various times after EEDQ injection. These results suggest that loss of striatal dopamine receptors during aging may be due to a decreased biosynthetic rate.
ISSN:0024-3205
DOI:10.1016/0024-3205(84)90416-8