Effect of clonidine on potential-dependent sodium currents in sensory neurons

In experiments on rat pups we studied the effect of clonidine on potential-dependent Na+ currents in dorsal root ganglia by the voltage clamp method. Clonidine decreased the amplitude of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium currents. The range of acting concentrations and the abs...

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Published inBulletin of experimental biology and medicine Vol. 139; no. 1; pp. 38 - 42
Main Authors Katina, I E, Krylov, B V, Khrustaleva, R S, Shchegolev, B F, Tsyrlin, V A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.01.2005
Subjects
Analgesics - pharmacology
Animals
Clonidine - pharmacology
Ganglia, Spinal - cytology
Ganglia, Spinal - drug effects
Ganglia, Spinal - physiology
Membrane Potentials - drug effects
Neurons, Afferent - drug effects
Neurons, Afferent - physiology
Patch-Clamp Techniques
Rats
Rats, Wistar
Sodium Channel Blockers - pharmacology
Sodium Channels - drug effects
Sodium Channels - physiology
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Summary:In experiments on rat pups we studied the effect of clonidine on potential-dependent Na+ currents in dorsal root ganglia by the voltage clamp method. Clonidine decreased the amplitude of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium currents. The range of acting concentrations and the absence of modulatory effect of norepinephrine on the efficiency of clonidine-induced blockade of sodium currents suggest that this blockade results from a direct interaction of clonidine with sodium channels.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0206-5