FTIR-ATR studies of the effect of shear rate upon albumin adsorption onto polyurethaneurea

The effect of wall shear rate upon albumin adsorption onto a polyurethaneurea, Biomer® † † Biomer® is a registered trademark of Ethicon, Inc., USA. , was studied using FTIR-ATR spectroscopy. In these experiments, nondiffusion conrolled adsorption was observed from 10 mg/ml solutions at known wall sh...

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Bibliographic Details
Published inBiomaterials Vol. 7; no. 5; pp. 340 - 347
Main Authors Pitt, W.G., Cooper, S.L.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.09.1986
Subjects
Adsorption
albumin
Biocompatible Materials
Biomef
FTIR-ATR
Kinetics
Models, Chemical
Polymers
Polyurethanes
polyurethaneurea
protein adsorption
Protein Binding
protein desorption
Serum Albumin, Bovine
shear rate
Spectrophotometry, Infrared
Surface Properties
protein adsorption
shear rate
FTIR-ATR
albumin
polyurethaneurea
Polymers
protein desorption
Biomef
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Summary:The effect of wall shear rate upon albumin adsorption onto a polyurethaneurea, Biomer® † † Biomer® is a registered trademark of Ethicon, Inc., USA. , was studied using FTIR-ATR spectroscopy. In these experiments, nondiffusion conrolled adsorption was observed from 10 mg/ml solutions at known wall shear rates. Results show that increasing wall shear rate during adsorption does not significantly affect the adsorption kinetics, but does decrease the rate of protein desorption. These results suggest that albumin adsorbed at higher shear rates is more tightly bound to the surface. Comparison of the data to simple mathematical models suggests that more than one layer of protein adsorbs in 2 h.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(86)90004-9