The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma

• Published in: Toxicon (Oxford) Vol. 28; no. 11; p. 1364
• Main Authors: Dyr, J E, Suttnar, J, Simák, J, Fortová, H, Kornalík, F
• Format: Journal Article
• Language: English
• Published: England 1990
• Subjects: Animals; Blood Coagulation; Chromatography, High Pressure Liquid; Crotalid Venoms - pharmacology; Fibrin - metabolism; Fibrinogen - metabolism; Fibrinopeptide A - analysis; Fibrinopeptide A - metabolism; Fibrinopeptide B - analysis; Fibrinopeptide B - metabolism; Humans; Rats

The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in...