The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma

The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 28; no. 11; p. 1364
Main Authors Dyr, J E, Suttnar, J, Simák, J, Fortová, H, Kornalík, F
Format Journal Article
LanguageEnglish
Published England 1990
Subjects
Animals
Blood Coagulation
Chromatography, High Pressure Liquid
Crotalid Venoms - pharmacology
Fibrin - metabolism
Fibrinogen - metabolism
Fibrinopeptide A - analysis
Fibrinopeptide A - metabolism
Fibrinopeptide B - analysis
Fibrinopeptide B - metabolism
Humans
Rats
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Summary:The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in rat plasma, and no fibrinopeptides were released even after prolonged incubation. The results suggest strong, fast-acting irreversible neutralization of the enzyme activity in rat plasma.
ISSN:0041-0101
DOI:10.1016/0041-0101(90)90103-E