The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma
The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in...
Saved in:
Published in | Toxicon (Oxford) Vol. 28; no. 11; p. 1364 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
1990
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in rat plasma, and no fibrinopeptides were released even after prolonged incubation. The results suggest strong, fast-acting irreversible neutralization of the enzyme activity in rat plasma. |
---|---|
AbstractList | The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in rat plasma, and no fibrinopeptides were released even after prolonged incubation. The results suggest strong, fast-acting irreversible neutralization of the enzyme activity in rat plasma. |
Author | Dyr, J E Simák, J Kornalík, F Suttnar, J Fortová, H |
Author_xml | – sequence: 1 givenname: J E surname: Dyr fullname: Dyr, J E organization: Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia – sequence: 2 givenname: J surname: Suttnar fullname: Suttnar, J – sequence: 3 givenname: J surname: Simák fullname: Simák, J – sequence: 4 givenname: H surname: Fortová fullname: Fortová, H – sequence: 5 givenname: F surname: Kornalík fullname: Kornalík, F |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2087698$$D View this record in MEDLINE/PubMed |
BookMark | eNpNkM1OwzAQhH0oKm3hDUDyEQ6BdeykzrGqyo9UiUs5V2vHCYbGjhyDWp4eS0SI03yanZnDzsnEeWcIuWJwx4CV9wCCZZDwpoLbKgHPNhMy-7PPyXwY3gGAy6qckmkOcllWckaOuzdDUUfrHfUNRdpYFazL-uA7H61rqXHfp87QJhk0pvCXcYlSdtV-2CEGX6eq9i76EIM9_sd0CBjHSd8aR9HVtD_g0OEFOWvwMJjLURfk9WGzWz9l25fH5_Vqm2leLGMmoNSCcS1K4IUuBHIQnAvIJc9zJRoBWhnJaokKUddGA8dS8IJVXBdKyXxBrn93-0_VmXrfB9thOO3HD-Q_5hFf0Q |
CitedBy_id | crossref_primary_10_1007_BF00802851 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1016/0041-0101(90)90103-E |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Anatomy & Physiology Pharmacy, Therapeutics, & Pharmacology |
ExternalDocumentID | 2087698 |
Genre | Journal Article |
GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXKI AAXUO ABFNM ABFRF ABFYP ABGSF ABJNI ABLST ABMAC ABUDA ABXDB ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFJKZ AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJOXV AKIFW AKRWK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC C45 CGR CS3 CUY CVF DU5 EBS ECM EFJIC EIF EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM M34 M41 MO0 N9A NPM O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSU SSZ T5K TEORI TWZ WUQ XOL Y6R ZGI ZXP ~02 ~G- ~KM |
ID | FETCH-LOGICAL-c357t-406c413c46035c54a304334028322b4f40cbe81d8abaacdec03a6435193c5bb82 |
ISSN | 0041-0101 |
IngestDate | Sat Sep 28 08:35:02 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c357t-406c413c46035c54a304334028322b4f40cbe81d8abaacdec03a6435193c5bb82 |
PMID | 2087698 |
ParticipantIDs | pubmed_primary_2087698 |
PublicationCentury | 1900 |
PublicationDate | 1990-00-00 |
PublicationDateYYYYMMDD | 1990-01-01 |
PublicationDate_xml | – year: 1990 text: 1990-00-00 |
PublicationDecade | 1990 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Toxicon (Oxford) |
PublicationTitleAlternate | Toxicon |
PublicationYear | 1990 |
SSID | ssj0003896 |
Score | 1.3954539 |
Snippet | The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 1364 |
SubjectTerms | Animals Blood Coagulation Chromatography, High Pressure Liquid Crotalid Venoms - pharmacology Fibrin - metabolism Fibrinogen - metabolism Fibrinopeptide A - analysis Fibrinopeptide A - metabolism Fibrinopeptide B - analysis Fibrinopeptide B - metabolism Humans Rats |
Title | The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma |
URI | https://www.ncbi.nlm.nih.gov/pubmed/2087698 |
Volume | 28 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1baxQxFA5bRehL0dai9UIebFFsdC6Z7Mxj0ZZSsAhuoW8lk8mUIptZdCo7_R_-X79cnBnXC-rLEM6ZDWHPx5kvybkQ8kwU01jXuWY1Nh-MF0Kzgsc5A7OQShVJpFw7oHen4viMn5xn55PJ11HU0nVbvlI3v8wr-R-rQga72izZf7BsPykEGMO-eMLCeP61jUOvb5fmWNv4fcMWPsTOXL7U5qab6yGHBJ4NI0s-Ly1xhPNsjItWBwn_dLUcD6EAOMKUDZbgSwqAbAdPHhjtrFkCTMaVLV36SPn-bOFt5_BwMqQ7fLhuW-Njuof7qKu5u66PP_4gPsJCmi9eM2RRVCFjLxodUASny60giILTTfIxuOKRC41TX9b8J9_ujxn62XbtFemu_ZrGUcoOxz-BlRZzZ_PEVtzzba7_qFypuR00a2Rtmlu3eWqPgMLnHQxP-LAFv47v-ZixeN3LnhfRi7CudXInzLaycXEEZnaXbISdBz3wMLpHJtpskq0DI9tm3tE96mKB3SXLJtl77yuad_t0NiTofd53r_W1zrstsoSaegjSpqaSrkKQeghSC0EKCFIHQfvuCIJ0wN14CAUgSAcIUkCQegjeJ2dHh7M3xyw082AqzaYtA3FUIEyKiyjNVMZlakvncdcqKyl5zSNVamyecllKqSqtolSCLdsNhsrKMk-2yS3TGP2A0FyISvAoLyrLp6u6yLQopI0sBt8G3XxItv0ffbHwFVsuggV2fqd4RNYH5D4mt2s4CP0EbLMtnzrrfwP8jnnv |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+action+of+a+fibrin-promoting+enzyme+from+the+venom+of+Agkistrodon+contortrix+contortrix+on+rat+fibrinogen+and+plasma&rft.jtitle=Toxicon+%28Oxford%29&rft.au=Dyr%2C+J+E&rft.au=Suttnar%2C+J&rft.au=Sim%C3%A1k%2C+J&rft.au=Fortov%C3%A1%2C+H&rft.date=1990-01-01&rft.issn=0041-0101&rft.volume=28&rft.issue=11&rft.spage=1364&rft_id=info:doi/10.1016%2F0041-0101%2890%2990103-E&rft_id=info%3Apmid%2F2087698&rft_id=info%3Apmid%2F2087698&rft.externalDocID=2087698 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0041-0101&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0041-0101&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0041-0101&client=summon |