Local cerebral glucose utilization in epileptic seizures of the mutant El mouse

The neural pathway and the focus of the epileptic seizure of mutant El mice were studied by the [14C]2-deoxyglucose technique. In the mice with full tonic-clonic seizure, the entire neocortex and hippocampus showed a remarkably increased metabolic rate. By contrast, a lower metabolic rate was eviden...

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Bibliographic Details
Published inBrain research Vol. 266; no. 2; p. 359
Main Authors Suzuki, J, Nakamoto, Y, Shinkawa, Y
Format Journal Article
LanguageEnglish
Published Netherlands 05.05.1983
Subjects
Animals
Brain - metabolism
Carbon Radioisotopes
Cerebral Cortex - metabolism
Deoxy Sugars - metabolism
Deoxyglucose - metabolism
Hippocampus - metabolism
Mice
Mice, Mutant Strains
Organ Specificity
Seizures - metabolism
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Summary:The neural pathway and the focus of the epileptic seizure of mutant El mice were studied by the [14C]2-deoxyglucose technique. In the mice with full tonic-clonic seizure, the entire neocortex and hippocampus showed a remarkably increased metabolic rate. By contrast, a lower metabolic rate was evident in the thalamic nuclei, central gray, locus coeruleus and some interstitial nuclei. The epileptic focus in El mice presumably exists in the hippocampus.
ISSN:0006-8993
DOI:10.1016/0006-8993(83)90670-4