Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers

• Published in: Radiotherapy and oncology Vol. 25; no. 1; pp. 37 - 42
• Main Authors: Stratford, M.R.L., Rojas, A., Hall, D.W., Dennis, M.F., Dische, S., Joiner, M.C., Hodgkiss, R.J.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.1992
• Subjects: Administration, Oral; Adult; Blood pressure; Blood Pressure - drug effects; Body Temperature - drug effects; Carbon Dioxide; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolites; Niacinamide - administration & dosage; Niacinamide - pharmacokinetics; Niacinamide - pharmacology; Nicotinamide; Oxygen; Pharmacokinetics; Plasma; Pulse; Pulse - drug effects; Radiation-Sensitizing Agents; Temperature; Urine; Urine; Plasma; Temperature; Metabolites; Humans; Pulse; Nicotinamide; Blood pressure; Pharmacokinetics
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/0167-8140(92)90193-X

The pharmacokinetics of nicotinamide were studied in four human volunteers after oral doses of 1–6 g. Plasma concentrations and clearance rates of the vitamin were found to be dose-dependent, with a half-life of ∼7–9 h for the two highest doses administered (4 and 6 g), ∼4 h with 2 g and ∼1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1 μmol·ml −1 after a 6-g dose. The time to reach peak plasma concentration was dose independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no detectable effect on blood pressure, pulse or body temperature.