Toxicology of tert-butylhydroquinone (TBHQ)

This paper traces the history of the EEC Scientific Committee for Food's examination of available toxicological data on tert-butylhydroquinone (TBHQ). Studies of mutagenicity, metabolism, enzyme activities, reproduction and long-term toxicity and carcinogenicity are reviewed. The author conclud...

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Bibliographic Details
Published inFood and chemical toxicology Vol. 24; no. 10; pp. 1063 - 1065
Main Author van Esch, G.J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1986
Subjects
Animals
Carcinogens
Humans
Hydroquinones - metabolism
Hydroquinones - toxicity
Mutagens
Stomach Neoplasms - chemically induced
JECFA
TBHQ
ADI
SCF
FDRL
BHA
BHT
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Summary:This paper traces the history of the EEC Scientific Committee for Food's examination of available toxicological data on tert-butylhydroquinone (TBHQ). Studies of mutagenicity, metabolism, enzyme activities, reproduction and long-term toxicity and carcinogenicity are reviewed. The author concludes that dose level is an important factor in the induction of forestomach tumours. Further long-term toxicity testing of TBHQ is needed to evaluate its genotoxicity. However, since information is not available, an attempt is made to calculate the ‘safety’ margin between actual intake by man and the conventional no-effect level in dogs and rats.
ISSN:0278-6915
1873-6351
DOI:10.1016/0278-6915(86)90289-9