2,3,7,8-tetrachlorodibenzo- P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at...

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Bibliographic Details
Published inAdvances in enzyme regulation Vol. 31; pp. 307 - 317
Main Authors Lusska, Amy E., Jones, Keith W., Elferink, Cornelis J., Wu, Lena, Shen, Emily S., Wen, Long-Ping, Whitlock, James P.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1991
Subjects
Animals
Aryl Hydrocarbon Hydroxylases - biosynthesis
Aryl Hydrocarbon Hydroxylases - genetics
Cell Line
Chromatin - drug effects
Chromatin - physiology
Enhancer Elements, Genetic - drug effects
Enzyme Induction
Gene Expression Regulation, Enzymologic - drug effects
Liver Neoplasms, Experimental
Mice
Polychlorinated Dibenzodioxins - pharmacology
Receptors, Aryl Hydrocarbon
Receptors, Drug - drug effects
Receptors, Drug - physiology
Transcription, Genetic - drug effects
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Summary:We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0065-2571
1873-2437
DOI:10.1016/0065-2571(91)90019-I