Mechanisms of Paraneoplastic Syndromes in Mice Bearing a Spontaneous Lung Adenocarcinoma

• Published in: Tumor biology Vol. 20; no. 6; pp. 304 - 311
• Main Authors: Parma, M., Diament, M., García, C., Piccinni, E., Mondelo, N., Klein, S.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.11.1999; Springer Nature B.V
• Subjects: Adenocarcinoma - blood; Adenocarcinoma - pathology; Adenocarcinoma - physiopathology; Alanine Transaminase - blood; Alkaline Phosphatase - blood; Animals; Aspartate Aminotransferases - blood; Biological and medical sciences; Blood Proteins - analysis; Cachexia - physiopathology; Calcium - blood; Female; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis; Hematocrit; Leukocyte Count; Lung Neoplasms - blood; Lung Neoplasms - pathology; Lung Neoplasms - physiopathology; Medical sciences; Mice; Mice, Inbred BALB C; Original Paper; Paraneoplastic Syndromes - blood; Paraneoplastic Syndromes - physiopathology; Parathyroid Hormone-Related Protein; Pneumology; Proteins - analysis; Tropical medicine; Tumor Cells, Cultured; Tumors of the respiratory system and mediastinum; Hypercalcemia; Murine lung tumor; Paraneoplastic syndromes; PTHrP; pQCT; Adenocarcinoma; Animal model; Hydroelectrolytic balance disorder; Spontaneous; Inorganic element; Bronchopulmonary; Bronchus disease; Serum; Tumor necrosis factor α; Lung disease; Biochemical analysis; Respiratory disease; Cytokine; Rodentia; Cachexia; Malignant tumor; Pathology; Metabolic disorder; Vertebrata; Mammalia; Mouse; Animal; Parathyroid hormone related peptide; Paraneoplastic syndrome; Granulocyte macrophage colony stimulating factor
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1159/000030094

Paraneoplastic syndromes are rarely described in animal models. It may be useful to have a suitable experimental model to study the mechanisms by which they are produced. In this study, we describe a murine lung adenocarcinoma, P07, which presents hypercalcemia, leukocytosis and cachexia. We determined the presence of PTHrP in plasma as well as GM-CSF produced by P07 cells. TNF-α, which is responsible for cachexia, could neither be detected in serum nor in P07 cell supernatants. We conclude that this model, which shows paraneoplastic syndromes similar to those of lung tumor patients, should be useful to study the pathways and significance of these signs.