Glycosaminoglycan synthesis by mammary tumor spheroids

Multicellular aggregates of tumorigenic mouse mammary epithelial cells contain a hyaluronate-rich matrix, both at the aggregate periphery and within the growing spheroid. It is proposed that the establishment of a hyaluronaterich matrix is essential to spheroid growth in vitro, and that the spheroid...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 107; no. 3; pp. 1130 - 1137
Main Authors Angello, John C., Hosick, Howard L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1982
Subjects
Animals
Carbon Radioisotopes
Cell Aggregation
Female
Glucosamine - metabolism
Glycosaminoglycans - biosynthesis
Kinetics
Mammary Neoplasms, Experimental - metabolism
Mice
TCA
STV
CPC
HA
HS
GAG
CMF
MTS
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Summary:Multicellular aggregates of tumorigenic mouse mammary epithelial cells contain a hyaluronate-rich matrix, both at the aggregate periphery and within the growing spheroid. It is proposed that the establishment of a hyaluronaterich matrix is essential to spheroid growth in vitro, and that the spheroid is a good model system for analysis of this aspect of early tumor development.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(82)90639-8