Lysosomal enzymes in 7, 12-dimethylbenz[a]anthracene-induced mammary carcinomas after ovariectomy

• Published in: European journal of cancer Vol. 9; no. 4; pp. 313 - 318
• Main Authors: Nicholson, Robert I., Bagnall, Irene, Davies, Malcolm
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.1973
• Subjects: Animals; Benz(a)Anthracenes; Castration; DNA, Neoplasm - metabolism; Female; Hydrolases - metabolism; Lysosomes - enzymology; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - enzymology; Neoplasm Proteins - metabolism; Neoplasm Regression, Spontaneous; Ovary - physiology; Peptide Hydrolases - metabolism; Rats; RNA, Neoplasm - metabolism

The activities of the five acid hydrolases together with protein, DNA, and RNA were established in growing tumours and in tumours five days after ovariectomy. Although variations were recorded between the individual enzymes, the general trend was an increase in the specific activity of the five acid...