Lysosomal enzymes in 7, 12-dimethylbenz[a]anthracene-induced mammary carcinomas after ovariectomy

The activities of the five acid hydrolases together with protein, DNA, and RNA were established in growing tumours and in tumours five days after ovariectomy. Although variations were recorded between the individual enzymes, the general trend was an increase in the specific activity of the five acid...

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Bibliographic Details
Published inEuropean journal of cancer Vol. 9; no. 4; pp. 313 - 318
Main Authors Nicholson, Robert I., Bagnall, Irene, Davies, Malcolm
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1973
Subjects
Animals
Benz(a)Anthracenes
Castration
DNA, Neoplasm - metabolism
Female
Hydrolases - metabolism
Lysosomes - enzymology
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - enzymology
Neoplasm Proteins - metabolism
Neoplasm Regression, Spontaneous
Ovary - physiology
Peptide Hydrolases - metabolism
Rats
RNA, Neoplasm - metabolism
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Summary:The activities of the five acid hydrolases together with protein, DNA, and RNA were established in growing tumours and in tumours five days after ovariectomy. Although variations were recorded between the individual enzymes, the general trend was an increase in the specific activity of the five acid hydrolases. The most marked increase in activity was recorded with acid proteinase, an important enzyme involved in the breakdown of tissue components. The results indicate that the pattern observed for the regressing tumour is similar to that observed for normal hormone-dependent tissue undergoing physiological changes.
ISSN:0014-2964
DOI:10.1016/0014-2964(73)90100-X