A controlled study of amitriptyline in the treatment of chronic pain

This paper reports a study in which a double-blind controlled cross-over study of amitriptyline vs. placebo was carried out in a group of patients referred to a multidisciplinary pain clinic for the management of chronic intractable pain for which no substantial organic cause could be demonstrated....

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Bibliographic Details
Published inPain (Amsterdam) Vol. 14; no. 2; pp. 169 - 179
Main Authors Pilowsky, I., Hallett, E.C., Bassett, D.L., Thomas, P.G., Penhall, R.K.
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.10.1982
Subjects
Amitriptyline - adverse effects
Amitriptyline - blood
Amitriptyline - therapeutic use
Chronic Disease
Clinical Trials as Topic
Female
Humans
Male
Pain - drug therapy
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Summary:This paper reports a study in which a double-blind controlled cross-over study of amitriptyline vs. placebo was carried out in a group of patients referred to a multidisciplinary pain clinic for the management of chronic intractable pain for which no substantial organic cause could be demonstrated. Of 52 patients entering the 12-week trial, 20 withdrew before completion. No differences were found in terms of global improvement on either agent. Subjective reports indicated a greater reduction in pain at 2 and 4 weeks on amitriptyline, but no difference at 6 weeks. None of the baseline measures was predictive of response.
ISSN:0304-3959
1872-6623
DOI:10.1016/0304-3959(82)90097-5