The effect of beta-endorphin on basal and TRH-stimulated TSH release in conscious male rats

The inhibitory effect of beta-endorphin (EP) or other opioids on TSH secretion is, in contrast to their stimulating properties on PRL release, still a matter of debate. In the present study a dose of 1 microgram beta-EP injected intracerebroventricularly (IVT) in unstressed conscious male rats, thou...

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Published inHormone and metabolic research Vol. 20; no. 11; p. 687
Main Authors Buydens, P, Velkeniers, B, Golstein, J, Finné, E, Vanhaelst, L
Format Journal Article
LanguageEnglish
Published Germany 01.11.1988
Subjects
Animals
beta-Endorphin - physiology
Male
Prolactin - blood
Rats
Thyrotropin - blood
Thyrotropin - metabolism
Thyrotropin-Releasing Hormone - physiology
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Summary:The inhibitory effect of beta-endorphin (EP) or other opioids on TSH secretion is, in contrast to their stimulating properties on PRL release, still a matter of debate. In the present study a dose of 1 microgram beta-EP injected intracerebroventricularly (IVT) in unstressed conscious male rats, though highly effective on PRL release, did not affect basal TSH levels, nor the TRH-induced TSH secretion. The previously reported inhibition of TSH release by opioids may therefore be an effect only seen when pharmacological doses are used.
ISSN:0018-5043
DOI:10.1055/s-2007-1010917