Serum growth arrest-specific protein 6 levels are elevated in adult-onset Still’s disease

• Published in: Clinical rheumatology Vol. 33; no. 6; pp. 865 - 868
• Main Authors: Kim, Hyoun-Ah, Nam, Jin-Young, Jung, Ju-Yang, Bae, Chang-Bum, An, Jeong-Mi, Jeon, Ja-Young, Kim, Bong-Sik, Suh, Chang-Hee
• Format: Journal Article
• Language: English
• Published: London Springer London 01.06.2014; Springer Nature B.V
• Subjects: Adult; Biomarkers - blood; Brief Report; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Reproducibility of Results; Republic of Korea; Rheumatology; Still's Disease, Adult-Onset - blood; Republic of Korea; Biomarker; Disease activity; Growth arrest-specific protein 6; Adult onset Still’s disease
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-014-2629-8

We investigated the growth arrest-specific protein 6 in adult-onset Still’s disease. Serums were collected from 52 adult-onset Still’s disease patients with follow-up samples of 21 patients. The growth arrest-specific protein 6 levels in adult-onset Still’s disease were higher compared to those in the normal controls (25.37 ± 7.71 vs. 19.86 ± 5.01 ng/mL, p  < 0.001). However, growth arrest-specific protein 6 did not correlate with disease activity. Also, growth arrest-specific protein 6 was not decreased after activity was resolved in the follow-up. The growth arrest-specific protein 6 in adult-onset Still’s disease patients were higher than the normal controls. However, growth arrest-specific protein 6 was not correlated with disease activity.