Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination

Our research regarding side-chain fluorinated vitamin D3 analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D3 side-chain was developed using N-fluorobenzenesulfonimid...

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Bibliographic Details
Published inBiomolecules (Basel, Switzerland) Vol. 14; no. 1; p. 37
Main Authors Kawagoe, Fumihiro, Mototani, Sayuri, Kittaka, Atsushi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.01.2024
Subjects
Acids
Chloride
Chromatography
electrophilic fluorination
Evans chiral auxiliary
Fourier transforms
Metabolism
N-fluorobenzenesulfonimide (NFSI)
side-chain
side-chain fluorinated vitamin D3
Vitamin D3
Japan
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Summary:Our research regarding side-chain fluorinated vitamin D3 analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D3 side-chain was developed using N-fluorobenzenesulfonimide (NFSI) and CD-ring imides with an Evans chiral auxiliary (26,27,30).
Bibliography:ObjectType-Article-1
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ISSN:2218-273X
2218-273X
DOI:10.3390/biom14010037