Experimental aspiration pneumonia: Hemodynamics, ventilator and membrane oxygenator support

Cardiopulmonary hemodynamics were studied in anaesthetized mongrel dogs following massive aspiration. Severe hypoxia and acidosis, volume deficit, decreased cardiac output and increased pulmonary resistance were prominent findings, while overt left heart failure does not appear to play an important...

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Bibliographic Details
Published inThe Journal of surgical research Vol. 16; no. 4; pp. 324 - 329
Main Authors Maclaren Toussaint, G.P., Chiu, Chu-Jeng, Hampson, L.G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1974
Subjects
Animals
Cardiac Output
Dogs
Hemodynamics
Lung - pathology
Oxygenators, Membrane
Pneumonia, Aspiration - physiopathology
Positive-Pressure Respiration
Pulmonary Circulation
Pulmonary Edema - etiology
Respiration, Artificial
Vascular Resistance
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Summary:Cardiopulmonary hemodynamics were studied in anaesthetized mongrel dogs following massive aspiration. Severe hypoxia and acidosis, volume deficit, decreased cardiac output and increased pulmonary resistance were prominent findings, while overt left heart failure does not appear to play an important role in the early stage of aspiration pneumonia. The use of mechanical ventilator support, with added oxygen if needed, is associated with improved oxygenation, more stable hemodynamics and more prolonged survival. In situations where PPV is ineffective due to massive shunting of blood in the lung, effective oxygenation is possible using the membrane oxygenator.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-4804
1095-8673
DOI:10.1016/0022-4804(74)90050-X