A rapid procedure for the isolation of drugs and drug metabolites from plasma

• Published in: Clinica chimica acta Vol. 37; pp. 381 - 386
• Main Authors: Horning, Marjorie G., Boucher, E.Ann, Stafford, Michele, Horning, Evan C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.1972
• Subjects: 1-Propanol; Animals; Caffeine - blood; Caffeine - isolation & purification; Carbon Isotopes; Carbonates; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids - blood; Humans; Mass Spectrometry; Methods; Methylation; Phenobarbital - blood; Phenobarbital - isolation & purification; Potassium; Rats; Silicon

A rapid procedure for the extraction of neutral and basic drugs and drug metabolites with isopropanol from diluted plasma saturated with potassium carbonate has been developed. The isopropanol extract is suitable for analysis by thin layer or gas chromatography. Recovery experiments (radioactivity)...