A rapid procedure for the isolation of drugs and drug metabolites from plasma

A rapid procedure for the extraction of neutral and basic drugs and drug metabolites with isopropanol from diluted plasma saturated with potassium carbonate has been developed. The isopropanol extract is suitable for analysis by thin layer or gas chromatography. Recovery experiments (radioactivity)...

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Bibliographic Details
Published inClinica chimica acta Vol. 37; pp. 381 - 386
Main Authors Horning, Marjorie G., Boucher, E.Ann, Stafford, Michele, Horning, Evan C.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.1972
Subjects
1-Propanol
Animals
Caffeine - blood
Caffeine - isolation & purification
Carbon Isotopes
Carbonates
Chromatography, Gas
Chromatography, Thin Layer
Fatty Acids - blood
Humans
Mass Spectrometry
Methods
Methylation
Phenobarbital - blood
Phenobarbital - isolation & purification
Potassium
Rats
Silicon
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Summary:A rapid procedure for the extraction of neutral and basic drugs and drug metabolites with isopropanol from diluted plasma saturated with potassium carbonate has been developed. The isopropanol extract is suitable for analysis by thin layer or gas chromatography. Recovery experiments (radioactivity) with phenobarbital and caffeine gave 100 ± 5% recovery. The absence of emulsions contributes to the high recovery.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(72)90458-5