Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome

• Published in: Bulletin of experimental biology and medicine Vol. 142; no. 5; pp. 554 - 556
• Main Authors: Krupina, N A, Zolotov, N N, Bogdanova, N G, Orlova, I N, Khlebnikova, N N, Kryzhanovskii, G N
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.11.2006
• Subjects: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain - enzymology; Cerebral Cortex - drug effects; Cerebral Cortex - enzymology; Depressive Disorder - chemically induced; Depressive Disorder - metabolism; Dipeptidyl Peptidase 4 - metabolism; Dopamine - deficiency; Hypothalamus - enzymology; Male; Rats; Rats, Wistar; Serine Endopeptidases - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-006-0416-5

The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the target structures of the brain dopaminergic system are involved in the pathogenesis of dopamine deficiency-dependent depressive states.