Salt and Hypertension in End-Stage Renal Disease

• Published in: Blood purification Vol. 16; no. 6; pp. 301 - 311
• Main Authors: Kooman, J.P., Leunissen, K.M.L., Luik, A.J.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 1998
• Subjects: Biological and medical sciences; Circadian Rhythm; Diet, Sodium-Restricted; Edema - etiology; Edema - physiopathology; Editorial Review; Genetic Predisposition to Disease; Genetic Variation; Hemodynamics; Humans; Hypertension - etiology; Hypertension - physiopathology; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - physiopathology; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - physiopathology; Medical sciences; Mitral Valve Insufficiency - etiology; Mitral Valve Insufficiency - physiopathology; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Norepinephrine - physiology; Renal Dialysis - adverse effects; Renal failure; Renin-Angiotensin System - physiology; Sodium Chloride - adverse effects; Sodium, Dietary - adverse effects; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors; Sodium-Potassium-Exchanging ATPase - physiology; Sympathetic Nervous System - physiopathology; Water-Electrolyte Imbalance - complications; Water-Electrolyte Imbalance - physiopathology; Hypertension; Salt; End-stage renal disease; Dialysis; Sodium; Uremia; Kidney disease; Human; Urinary system disease; Renal failure; Cardiovascular disease; Complication; Terminal stage; Hydric overload; Salt overload
• ISSN: 0253-5068; 1421-9735
• DOI: 10.1159/000014349

Salt and fluid overload play an important role in the pathogenesis of hypertension in patients with end-stage renal disease. However, in the individual patient, the relation between salt loading and blood pressure response is variable and appears to be influenced by various neurohumoral regulatory mechanisms. This may also have implications for the pathogenesis of structural cardiovascular abnormalities in patients with end-stage renal disease.