An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia

• Published in: Journal of Neural Transmission Vol. 112; no. 11; pp. 1575 - 1582
• Main Authors: Rybakowski, J K, Borkowska, A, Czerski, P M, Kapelski, P, Dmitrzak-Weglarz, M, Hauser, J
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.11.2005
• Subjects: Adolescent; Adult; Brain - metabolism; Brain - physiopathology; Brain Chemistry - genetics; DNA Mutational Analysis; Dopamine - metabolism; Female; Genetic Predisposition to Disease - genetics; Genetic Testing; Genotype; Humans; Male; Mutation - genetics; Neuropsychological Tests; Polymorphism, Genetic - genetics; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Receptors, Dopamine - genetics; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenic Psychology; Sex Factors
• ISSN: 0300-9564; 1435-1463
• DOI: 10.1007/s00702-005-0292-6

Dopamine (DA), an important neurotransmitter in prefrontal cortex (PFC), is involved in the pathogenesis of schizophrenia. The aim of the study was to test an association between common polymorphism of genes for DA receptors DRD1, DRD2, DRD3, DRD4, and performance on the Wisconsin Card Sorting Test (WCST), measuring various functions of PFC, in 138 schizophrenic patients. Patients with G/G genotype of DRD1 tended to obtain worse results in all domains of WCST compared to patients with remaining genotypes, particularly for number of completed corrected categories, and trials to set the first category. A relationship was also found in female patients between DRD2 polymorphism and number of perseverative errors, while no association between WCST results and DRD3 or DRD4 polymorphism was observed in patients studied. The results may suggest an association between DRD1 gene polymorphism and performance on PFC test in schizophrenia. Also, the gender-dependent role of DRD2 in this process may be presumed.