Pharmacokinetics and urinary excretion of gentamicin in Bubalus bubalis calves following intramuscular administration

The pharmacokinetics and urinary excretion of gentamicin was studied in buffalo calves after a single intramuscular administration (10 mg kg-1). Kinetic determinants were calculated by using a two compartment open model. The absorption (t1/2Ka) and biological half lives (t1/2 beta) were calculated t...

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Bibliographic Details
Published inResearch in veterinary science Vol. 50; no. 1; p. 102
Main Authors Garg, S K, Verma, S P, Garg, B D
Format Journal Article
LanguageEnglish
Published England 01.01.1991
Subjects
Absorption
Animals
Buffaloes - metabolism
Buffaloes - urine
Gentamicins - administration & dosage
Gentamicins - pharmacokinetics
Gentamicins - urine
Half-Life
Injections, Intramuscular - veterinary
Male
Tissue Distribution
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Summary:The pharmacokinetics and urinary excretion of gentamicin was studied in buffalo calves after a single intramuscular administration (10 mg kg-1). Kinetic determinants were calculated by using a two compartment open model. The absorption (t1/2Ka) and biological half lives (t1/2 beta) were calculated to be 0.43 +/- 0.08 and 3.79 +/- 0.23 h, respectively. The value of the apparent volume of distribution (VdB) was found to be 0.38 +/- 0.07 litre kg-1. The satisfactory intramuscular dosage regimen of gentamicin for buffalo calves would be 3.23 mg kg-1 as priming dose and 2.88 mg kg-1 as maintenance dose to be repeated at 12 hour intervals to achieve and maintain the therapeutic plasma levels within safe limits. Urinary excretion of gentamicin was very rapid during the first 12 hours as 48.07 +/- 1.39 per cent of the total administered dose was excreted unchanged during this period.
ISSN:0034-5288
1532-2661
DOI:10.1016/0034-5288(91)90061-R