Click Multivalent Heterogeneous Neoglycoconjugates - Modular Synthesis and Evaluation of Their Binding Affinities

• Published in: European Journal of Organic Chemistry Vol. 2009; no. 15; pp. 2454 - 2473
• Main Authors: Ortega-Muñoz, Mariano, Perez-Balderas, Francisco, Morales-Sanfrutos, Julia, Hernandez-Mateo, Fernando, Isac-García, Joaquín, Santoyo-Gonzalez, Francisco
• Format: Book Review Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.05.2009; WILEY‐VCH Verlag; Wiley; Wiley-VCH
• Subjects: Carbohydrates; Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides; Carbohydrates. Nucleosides and nucleotides; Chemistry; Chemistry, Organic; Click chemistry; Cycloaddition; Exact sciences and technology; Glycoconjugates; Ligand design; Multivalency; Organic chemistry; Physical Sciences; Preparations and properties; Science & Technology; Carbohydrates; Glycoconjugates; FUNCTIONALIZED DENDRIMERS; LIGATION; PREDICTABLE TUNABILITY; SUPRAMOLECULAR CHEMISTRY; 1,3-DIPOLAR CYCLOADDITION REACTION; Cycloaddition; Multivalency; CHEMICAL BIOLOGY; LECTIN; Ligand design; AZIDE-ALKYNE CYCLOADDITIONS; D-GALACTOPYRANOSIDES; OCTOPUS GLYCOSIDES; Click chemistry; Lectin; Aldose; Ligand; Glycoprotein; Oside; Mannose; Glycoconjugate; Concanavalin A; Binding protein; Binding capacity; Chemical synthesis; Heterogeneous reaction

The efficient synthesis of structurally diverse, multivalent, heterogeneous neoglycoconjugates by means of a series of different click‐based strategies is described. The methodology is highly efficient and versatile allowing for easy access to a series of mannose (α‐Man)‐containing glycoconjugates d...